The DFI test (DNA Fragmentation Index test) is a test that is used to determine the proportion of broken DNA within the sperm cells. At Mannat Fertility Centre, Bangalore, DFI testing costs between 3,000 and 5,000, with the results in 3 to 5 days. A normal DFI is below 15%. Failure to conceive IVF cycles, recurrent miscarriage and poor embryo development are linked to DFI of over 30 percent even with a normal semen analysis.

What is DFI Test? Full Form, Meaning and What it Measures?

The DFI test determines the proportion of sperm in a sample that bears damaged DNA; an element that cannot be determined through the normal semen analysis. Sperm with intact DNA fertilise eggs more reliably and produce healthier embryos; directly improving IVF and natural conception outcomes. High levels of DNA Fragmentation Index affect a person’s ability to get pregnant and increase their risk of pregnancy loss as well as reduce their success rate when using assisted reproductive methods.

The DNA Fragmentation Index (DFI) testing delivers crucial information about male fertility, which standard semen analysis cannot provide so it proves particularly beneficial for couples experiencing unexplained infertility, repeated IVF failures or recurrent pregnancy loss.

DFI Normal Range:

  • Below 15% — Normal. Good prognosis of natural conception and IVF.
  • 15% to 30% — Borderline. The natural conception can be sluggish. IUI is not recommended. ICSI IVF increases the results.
  • Above 30% — High fragmentation. Linked to unsuccessful IVF, frequent miscarriage, and low embryo quality. The following cycle is followed by ICSIs with sperm selection or antioxidant treatment.
  • Above 50% — Severe. Donor sperms or sperm retrieval through surgery can be taken into consideration.

In Mannat Fertility Centre, the interpretation of DFI results is done in a follow-up consultation by a reproductive specialist, not by simply e-mailing a number.