In Human ejaculate, there is a dynamic interaction between anti-oxidant and pro-oxidant. If ROS (Reactive Oxygen Species) is low, plays a vital physiological role by modulating gene and protein activities for proliferation, function, and differentiation.
There is a dynamic interplay between pro- and anti-oxidant substances in the human ejaculate. Reactive oxygen species (ROS) in low, controlled levels in the extracellular space play an important physiological role, modulating gene and protein activities vital for sperm proliferation, differentiation, and function. Excessive reactive oxygen species (ROS) generation can overwhelm the protective mechanism and initiate changes in lipid and/or protein layers of sperm plasma membranes. Additionally, changes in DNA can be induced.
Oxidative stress (OS) is outlined as a cellular condition related as the disparity between the assembly of free radicals, mainly ROS, and their sifting capability by antioxidants. Once the assembly of ROS exceeds the antioxidant defense, important oxidative destruction happens to several cellular organelles by destructive proteins, lipids, carbohydrates, and DNA, so ultimately resulting in the death of the cell. The Oxidative Stress-induced sperm cell destructive has been urged to be a major causative attribute in 40-70% of all circumstances of male physiological condition. The cohort of ROS may be impaired by infectious, environmental and manner aetiologies.
Well, reactive oxygen species have both advantages and disadvantages. Reactive oxygen species may be harmful to the cells in the body. With the presence of electrons, many macromolecules like as, proteins, nucleic acids and lipids can be damaged. According to scientific research, a reactive oxygen species can be harmful to the human being.
Reactive oxygen species includes an important source which is known as “Mitochondria”. Among the most mammalian cells, mitochondria are the most important source of ROS (reactive oxygen species). Other factors also affect the production of reactive oxygen species (ROS) like stress. Lots of stress has a great impact on ROS production.